Abacavir hydrochloride is a nucleoside reverse transcriptase inhibitor (NRTI)
Product Description
| Chemical name: | Abacavir HCL |
| CAS Number: | 136777-48-5 |
| Therapeutic Category: | Antiretroviral, Anti HIV |
| Route of Administration: | Solution , Tablet |
| Mechanism of Action: | Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent.Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA.Viral DNA growth is terminated because the incorporated nucleotide lacks a 3′-OH group, which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation. |
| Drug Indications: | Abacavir is indicated in combination with other anti-retroviral agents for the treatment of HIV-1 infection.Abacavir should always be used in combination with other antiretroviral agents. Abacavir should not be added as a single agent when antiretroviral regimens are changed due to loss of virologic respons |
Abacavir hydrochloride exists in the hydrochloride variant of Abacavir, which is also known as Ziagen (sc-338739). It functions as a nucleoside reverse transcriptase inhibitor (NRTI). NRTIs operate by obstructing the activity of HIV reverse transcriptase, an enzyme central to the HIV virus. Abacavir hydrochloride serves as a suppressor of HIV-1 RT, the reverse transcriptase enzyme specific to HIV-1.