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Abacavir HCl

Abacavir hydrochloride is a nucleoside reverse transcriptase inhibitor (NRTI)

Product Description

Chemical name: Abacavir HCL
CAS Number: 136777-48-5
Therapeutic Category: Antiretroviral, Anti HIV
Route of Administration: Solution , Tablet
Mechanism of Action: Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent.Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA.Viral DNA growth is terminated because the incorporated nucleotide lacks a 3′-OH group, which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation.
Drug Indications: Abacavir is indicated in combination with other anti-retroviral agents for the treatment of HIV-1 infection.Abacavir should always be used in combination with other antiretroviral agents. Abacavir should not be added as a single agent when antiretroviral regimens are changed due to loss of virologic respons

Abacavir hydrochloride exists in the hydrochloride variant of Abacavir, which is also known as Ziagen (sc-338739). It functions as a nucleoside reverse transcriptase inhibitor (NRTI). NRTIs operate by obstructing the activity of HIV reverse transcriptase, an enzyme central to the HIV virus. Abacavir hydrochloride serves as a suppressor of HIV-1 RT, the reverse transcriptase enzyme specific to HIV-1.

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