api

Acotiamide supplier & exporter

Product Description

Trader & Wholesaler of Acotiamide

Mechanism of Action:

Acotiamide exerts its gastroprokinetic activity via presynaptic M1 and M2 muscarinic receptor inhibition, resulting in enhanced acetylcholine (Ach) release, and via inhibition of AchE activity in the stomach

Drug Indications:

Acotiamide is used in the treatment of functional dyspepsia. It helps to relieve the symptoms like bloating after a meal, pain/discomfort in the upper abdomen and early satiety

Acitretin supplier & exporter

Product Description

Trader & Wholesaler of Acitretin

Mechanism of Action:

Acitretin works by inhibiting the excessive cell growth and keratinisation (process by which skin cells become thickened due to the deposition of a protein within them) seen in psoriasis. It therefore reduces the thickening of the skin, plaque formation and scaling.

Drug Indications:

Acitretin is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in only very severe cases of psoriasis that have been unresponsive to other treatments. It binds to nuclear receptors that regulates gene transcription.

Acetylcysteine supplier & exporter

Product Description

Trader & Wholesaler of Acetylcysteine

Mechanism of Action:

Acetylcysteine’s sulfhydryl groups may hydrolize disulfide bonds within mucin, breaking down the oligomers, and making the mucin less viscous.11,16 Acetylcysteine has also been shown to reduce mucin secretion in rat models.11 It is an antioxidant in its own right but is also deacetylated to cysteine, which participates in the synthesis of the antioxidant glutathione.11 The antioxidant activity may also alter intracellular redox reactions, decreasing phosphorylation of EGFR and MAPK, which decrease transcription of the gene MUC5AC which produces mucin.

Drug Indications:

acetaminophen is used for the treatment of mild to moderate pain and reduction of fever.23 It is available over the counter in various forms, the most common being oral forms.Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever

Acetazolamide supplier & exporter

Product Description

Trader & Wholesaler of Acetazolamide

Mechanism of Action:

Acetazolamide is a carbonic anhydrase inhibitor. The anticonvulsant activity of Acetazolamide may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water.

Drug Indications:

Acetazolamide is a diuretic and carbonic anhydrase inhibitor medication that is used to treat several illnesses. FDA-approved indications include glaucoma, idiopathic intracranial hypertension, congestive heart failure, altitude sickness, periodic paralysis, and epilepsy.

Acenocoumarol supplier & exporter

Product Description

Trader & Wholesaler of Acenocoumarol

Mechanism of Action:

Acenocoumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent clotting factors, this limitsanticoagulant proteins C and S is inhibited resulting in decreased prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins.

Drug Indications:

Acenocoumarol is an anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction.

Acefylline supplier & exporter

Product Description

Trader & Wholesaler of Acefylline

Mechanism of Action:

Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimulant effect on respiration. It stimulates the myocardium & central nervous system, decreases peripheral resistance & venous pressure & causes diuresis.

Drug Indications:

It is indicated for the treatment of asthma, emphysema, acute and chronic bronchitis associated with bronchospasm. Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimulant effect on respiration.

Aceclofenac supplier & exporter

Product Description

Trader & Wholesaler of Aceclofenac

Mechanism of Action:

Aceclofenac downregulates the production of various inflammatory mediators including prostaglandin E2 (PGE2), IL-1β, and TNF from the arachidonic acid (AA) pathway. Inhibition of IL-6 is thought to be mediated by diclofenac converted from aceclofenac 6. Suppressed action of inflammatory cytokines decreases the production of reactive oxygen species. Aceclofenac is shown to decreased production of nitrous oxide in human articular chondrocytes 2. In addition, aceclofenac interferes with neutrophil adhesion to endothelium by decreasing the expression of L-selectin (CD62L), which is a cell adhesion molecule expressed on lymphocytes

Drug Indications:

Aceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

Acebrophyline supplier & exporter

Product Description

Trader & Wholesaler of Acebrophylline

Mechanism of Action:

Acebrophylline modifies mucus secretion by lowering viscosity of ‘gel’ phase, increasing ‘sol’ phase and increases mucociliary clearance by augmenting ciliary motility

Drug Indications:

Acebrophylline is prescribed to reduce the irritation, swelling, and narrowing of the bronchial tubes in patients with asthma, severe or chronic bronchitis, chronic obstructive pulmonary disease (COPD)and tightness of the chest.

Acamprosate Calcium supplier & exporter

Product Description

Trader & Wholesaler of Acamprosate Calcium

Mechanism of Action:

The mechanism of action of acamprosate for the maintenance of alcohol abstinence has not been established. Chronic alcohol exposure is believed to modify the balance between neuronal excitation and inhibition. Results of studies in animals suggest acamprosate may interact with glutamate and GABA neurotransmitter systems in the CNS, supporting the hypothesis that acamprosate restores the balance between neuronal excitation and inhibition.3,11 Evidence shows that acamprosate directly binds and inhibits GABA B receptors and indirectly affects GABA A receptors.5,10

Drug Indications:

Acamprosate is indicated for the maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinent at treatment initiation. It is also indicated for the maintenance of alcohol abstinence in patients who have undergone alcohol detoxification. This drug should be used with a psychosocial support program providing adequate support.

Acalabrutinib supplier & exporter

Product Description

Trader & Wholesaler of Acalabrutinib

Mechanism of Action:

Acalabrutinib is a small molecule inhibitor of BTK. Both acalabrutinib and its active metabolite, ACP-5862, act to form a covalent bond with a cysteine residue (Cys481) in the BTK active site, leading to inhibition of BTK enzymatic activity.2,4 As a result, acalabrutinib inhibits BTK-mediated activation of downstream signaling proteins CD86 and CD69, which ultimately inhibits malignant B-cell proliferation and survival4

Drug Indications:

Acalabrutinib is currently indicated for the treatment of adult patients with Mantle Cell Lymphoma (MCL) who have received at least one prior therapy. It has also been recently approved for chronic lymphocytic leukemia and small lymphocytic lymphoma.