admin

Acenocoumarol supplier & exporter

Product Description

Trader & Wholesaler of Acenocoumarol

Mechanism of Action:

Acenocoumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent clotting factors, this limitsanticoagulant proteins C and S is inhibited resulting in decreased prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins.

Drug Indications:

Acenocoumarol is an anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction.

Acefylline supplier & exporter

Product Description

Trader & Wholesaler of Acefylline

Mechanism of Action:

Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimulant effect on respiration. It stimulates the myocardium & central nervous system, decreases peripheral resistance & venous pressure & causes diuresis.

Drug Indications:

It is indicated for the treatment of asthma, emphysema, acute and chronic bronchitis associated with bronchospasm. Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimulant effect on respiration.

Aceclofenac supplier & exporter

Product Description

Trader & Wholesaler of Aceclofenac

Mechanism of Action:

Aceclofenac downregulates the production of various inflammatory mediators including prostaglandin E2 (PGE2), IL-1β, and TNF from the arachidonic acid (AA) pathway. Inhibition of IL-6 is thought to be mediated by diclofenac converted from aceclofenac 6. Suppressed action of inflammatory cytokines decreases the production of reactive oxygen species. Aceclofenac is shown to decreased production of nitrous oxide in human articular chondrocytes 2. In addition, aceclofenac interferes with neutrophil adhesion to endothelium by decreasing the expression of L-selectin (CD62L), which is a cell adhesion molecule expressed on lymphocytes

Drug Indications:

Aceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

Acebrophyline supplier & exporter

Product Description

Trader & Wholesaler of Acebrophylline

Mechanism of Action:

Acebrophylline modifies mucus secretion by lowering viscosity of ‘gel’ phase, increasing ‘sol’ phase and increases mucociliary clearance by augmenting ciliary motility

Drug Indications:

Acebrophylline is prescribed to reduce the irritation, swelling, and narrowing of the bronchial tubes in patients with asthma, severe or chronic bronchitis, chronic obstructive pulmonary disease (COPD)and tightness of the chest.

Acamprosate Calcium supplier & exporter

Product Description

Trader & Wholesaler of Acamprosate Calcium

Mechanism of Action:

The mechanism of action of acamprosate for the maintenance of alcohol abstinence has not been established. Chronic alcohol exposure is believed to modify the balance between neuronal excitation and inhibition. Results of studies in animals suggest acamprosate may interact with glutamate and GABA neurotransmitter systems in the CNS, supporting the hypothesis that acamprosate restores the balance between neuronal excitation and inhibition.3,11 Evidence shows that acamprosate directly binds and inhibits GABA B receptors and indirectly affects GABA A receptors.5,10

Drug Indications:

Acamprosate is indicated for the maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinent at treatment initiation. It is also indicated for the maintenance of alcohol abstinence in patients who have undergone alcohol detoxification. This drug should be used with a psychosocial support program providing adequate support.

Acalabrutinib supplier & exporter

Product Description

Trader & Wholesaler of Acalabrutinib

Mechanism of Action:

Acalabrutinib is a small molecule inhibitor of BTK. Both acalabrutinib and its active metabolite, ACP-5862, act to form a covalent bond with a cysteine residue (Cys481) in the BTK active site, leading to inhibition of BTK enzymatic activity.2,4 As a result, acalabrutinib inhibits BTK-mediated activation of downstream signaling proteins CD86 and CD69, which ultimately inhibits malignant B-cell proliferation and survival4

Drug Indications:

Acalabrutinib is currently indicated for the treatment of adult patients with Mantle Cell Lymphoma (MCL) who have received at least one prior therapy. It has also been recently approved for chronic lymphocytic leukemia and small lymphocytic lymphoma.

Abiraterone Acetate supplier & exporter

Product Description

Trader & Wholesaler of Abiraterone Acetate

Drug Indications:

Abiraterone acetate is indicated in combination with methylprednisolone for the treatment of metastatic castration-resistant prostate cancer (CRPC)3 or with prednisone for the treatment of metastatic CRPC or metastatic high-risk castration-sensitive prostate cancer (CSPC).4

ProductName supplier & exporter

Product Description

Trader & Wholesaler of Abametapir

Mechanism of Action:

Abametapir is a metalloproteinase inhibitor that targets louse metalloproteinases which are critical to their development and hatching.The drug inhibits enzymes called metalloproteinases. In lice, these enzymes play a role in egg development and survival;[1] and consequently, blocking them will disrupt the lice’s life cycle.

Drug Indications:

Abametapir is indicated, in the context of an overall lice management program, for the topical treatment of head lice infestation in patients 6 months of age and older.

Abaloparatide supplier & exporter

Product Description

Trader & Wholesaler of Abaloparatide

Mechanism of Action:

abaloparatide acts as an agonist on PTH type 1 receptor (PTH1R) and activates both G protein–mediated cAMP signaling and β-arrestin-mediated ERK-1/2 signaling pathways with similar potency. Abaloparatide binds to RG conformation of PTH1R with greater selectivity that results in more transient cell signalling responses.

Drug Indications:

Investigated for use/treatment in postmenopausal osteoporosis to reduce vertebral and/or non-vertebral fractures.

Abacavir Sulfate supplier & exporter

Product Description

Trader & Wholesaler of Abacavir Sulfate

Mechanism of Action:

Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent.Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA.Viral DNA growth is terminated because the incorporated nucleotide lacks a 3′-OH group, which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation.

Drug Indications:

Abacavir is indicated in combination with other anti-retroviral agents for the treatment of HIV-1 infection.Abacavir should always be used in combination with other antiretroviral agents. Abacavir should not be added as a single agent when antiretroviral regimens are changed due to loss of virologic respons